I am on Hydroxy urea since early 2019. Platelets count fluctuates. So does the dosage of Hydroxy urea. 500 mg daily and additional 500 mg on alternate days. Aspirin 75 mg and antacid to keep gastro intestinal track in check is regular medicines. Physical activities throughout the day is must. A minimum of 10000 steps a day keep the blood flow normal. Plenty of water, about 4 liters helps in haemo-digestion of extra platelets I guess. Staying away from toxicity is most important as we can't afford to get sick with other chronic illness.