Was diagnosed with ET and JAK2 positive. Have been taking Hydrea 500mg and 81mg baby aspirin - both daily. In general, have good days and bad days something pretty normal when you are in your 70s. At times I do feel extra nauseous. My additional challenge is that I was scheduled to have Total Knee replacement in February which was cancelled due to ET and I cannot get injections until platelets are stable. My platelet level has been in the 500s for about 2 years. In January, I started bruising in my legs and my PCP referred me to my hematologist. I started Hydrea in March (with platelet level of 633) and after 2 weeks it went down to 486 and 2 weeks after that it went up to 531. After reading all the posts...this variation is to be expected. Last night I had such severe burning type pain from my hips down to knees ... feeling better after taking Celebrex. But I really, minimally need a knee injection. I am seeing my Hematologist next week and will discuss my concern. Has anyone felt the pain I described? - it may have just been my osteoarthritis.