Hi @bankerman, Since this crust in your nose seems to occur in winter, it could be related to the dryness of the air. If you live in a climate where you need a furnace during the winter months that can really rob moisture from the house.
I actually have a similar experience happen in the winter if the house is dry…been happening all my life and I’m now in my late 60s.
We have a whole house humidifier now, which has helped keep the moisture at the proper level. However, if it’s below zero for an extended period with the furnace cranking away, the air dries out again and I wake with a “crusty’…which loosens when I blow my nose. Some people are more prone to this than others for some reason. My husband never has this issue.

What has helped me to avoid my dry nose is a small vaporizer. Vicks makes one for a baby’s room. Small, quiet and easy to clean. I keep that plugged in and running near my side of the bed at night. I no longer have that nose problem with being dried out.
Another little trick is to apply a very light film of petroleum jelly inside your nostrils.
I also use a Xlear nasal spray morning and night to keep my sinuses clean and moisturized.
It’s good you had the area biopsied just to make sure the tissue was healthy.
Here’s a little article from Healthline.com regarding scabs in the nose that might be of some value. https://www.healthline.com/health/scabs-in-nose#diagnosis
Try your best to avoid removing it so that area can and see if it makes a difference. Have you tried upping the moisture in the house while sleeping or using any nasal moisturizers?