I am trying to research information about a possible side effect of Areds2 causing recurrent canker sores. Initially, I was taking 2 capsules as directed on the package: One in the morning, one in the evening / both with food. I noticed after about 2 weeks of following this direction that I had symptoms of overall 'uneasiness'. Difficult to describe, not quite nausea but general feeling of being unwell. As well, I started getting canker sores every 2 to 3 weeks. Also, the canker sores became more painful and severe as time went on requiring me to alternate ibuprofen and tylenol to ease the discomfort. I have started to take one Areds a day and note some improvement, but even then canker sores about 1 x a month. I cannot find any information to this issue and just wonder if anyone else on this particular site has had the same symptom.