I am on dofetilide (Tikosyn) and I have accidentally missed a dose before. Don't try to make up the missed dose. Just take your next dose at the usual time. If you did not experience any effects of missing the dose, I would not worry about informing your physician. Just my opinion. It's up to you. I have a pill box that allows me to set up my meds for the week. I find this really helpful since I take a few different meds, some in the morning and some in the evening.