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MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio

Blood Cancers & Disorders | Last Active: Aug 3 1:59pm | Replies (203)
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@michey

I didn't want to know much about my MGUS results although I was getting tested every 4 to 6 months for the first 2 years. (I guess life with the pandemic was enough for me!
Anyway, now I would like to understand my results that show:
1. IgG with Lambda Light Chain with Faint Bands"
2. High free Kappa Light Chain
3. High free Kappa Light Chain ratio
(Fortunately, the M Spike that I had appeared once last year is no longer appearing).
If anyone can explain these further or offer links to other references, I would be most appreciative. Thank you!

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Replies to "I didn't want to know much about my MGUS results although I was getting tested every..."
Colleen Young, Connect Director | @colleenyoung | Apr 26, 2023

Hi @michey, learning the language of a diagnosis can be daunting. I moved your questions about IgG and light chains to this existing discussion:
- MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio https://connect.mayoclinic.org/discussion/mgus-and-quite-high-free-kappa-light-chain-and-kappa-lambda-ratio/

I did this so you can read previous posts and connect easily with other member, like @pmm @gingerw @justnate @jart@ @packgb19 who asked similar questions and got answers about their blood results numbers as it applies to Lamba/Kappa light chains and ratios.

In the meantime, here's a good article that helps to explain light chains and their significance. - What Is Light Chain Myeloma? https://www.healthline.com/health/cancer/light-chain-myeloma

And 2 more articles about MGUS that you might find helpful
- Monoclonal gammopathy of undetermined significance (MGUS) https://www.mayoclinic.org/diseases-conditions/mgus/symptoms-causes/syc-20352362
How Serious Is Monoclonal Gammopathy of Undetermined Significance (MGUS)? https://www.healthline.com/health/how-serious-is-mgus

Michey, Were there significant changes to your latest blood numbers?

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