I have had fibromyalgia for about 35 years. It had spells escalating for a while, then would sort of level out for a while. Of course, it finally got to the point of being permanent with aches and pains. Doctor prescribed a few different "pain relief" meds; worthless. Several years ago a doctor prescribed Tramadol for back pain, due to degenerative disc disease, and arthritis. It did nothing at all for those pains, but I discovered that it DOES help fibromyalgia aches! My pain doctor now prescribes it---50 mg, three times a day. I take it the minute I wake up, and in about 45 minutes I can function much better. I would hate to be without it just for the fibromyalgia.