I took Ofev for a couple of years. The first 3 weeks after starting it were the worst. Stomach cramps, nausea, diarrhea, fatigue. Then my body seemed to adjust to it. I did take it with an antidiarhheal if I was going to be away from the house. Also drank a protein drink with it. Make sure you take it with a relatively high protein, not just carbs. And take it in the middle of your meal, dont wait five or ten minutes after you've eaten and then take it.