I'm thinking there probably are no studies for idiopathic since it means they don't know the cause so how can there be a study...just my right brain thinking 🙂 Here's some generic really good information about Alpha Lipoic Acid and how it works at a cellular level to help many different conditions by The Linus Pauling Institute at Oregon State University.
I was getting ready to order more A lipoic acid when i came across this thread. I see mine by Nature's Pure is a combo of R and S lipoic acid. I also take Vitamins. D3 and K2. L carnitine made me vomit 2 days in a row so I don't take it.
I had some neuropathy in my feet before I started chemo, but it didn't interfere with my life. After receiving Taxol, my feet became very numb and I had to stop driving. Some feeling has come back to my feet and I was able to make an 8 mile drive to a shopping center. Going was no problem; after the joy of being in a shopping center again and tromping around, my feet became numb and the drive home wasn't much fun. I've never had painful feet, just numb. I do believe my feet are better and I would recommend trying the 3 supplements I mentioned. You don't need a fancy brand. I also take phosphatidyl serine. It makes me feel relaxed. If you notice the ads for Prevagin and other brain supplements, the main ingredient is phosphatidyl serine and it's much easier and cheaper to buy a bottle of phosphatidyl serine on Amazon. I take 600mg of gabapentin a day. I've cut back from 900 a day.
Also discuss taking any medication and/or supplement by talking to your doctor or pharmacist. The Urologist I have been going to for years, after discussing with him the benefits of taking a supplement to improve my urination, he did recommend a supplement to improve my urination, which has been slowing down a bit - a common plight of elderly men.
I started off slow with Gabapentin about 18 months ago and now take 1800mg, 300mg in am, 600 in pm & 900 before bed. At this point, I don't want to stop for fear of the pain getting worse. The max dose for seizures is 3600mg. It is also prescribed for Restless Leg, which I think often accompanies the misery of PN. Does it work? Who knows. I have gained 8 lbs which at 72, will be difficult to shed. Back to strict Keto. People tell you to exercise, but just doing light housework & making myself presentable every day can be excruciating. This disease robs you of even the most simple comfort & pleasure.
Over about 4 months, I started at lower doses of Gabapentin until we seemed to hit a sweet spot at 800mg 3x daily. The benefits I receive from it are reduced intolerance to cold/heat in hands and feet reduction of the deep nerve pain associated with my PN. It might help some with the tingling, but nothing for numbness, but they aren’t painful. I am fortunate I don’t have side effects. My only worry had been when I let a dose go by and pain sets in, it usually takes about 2 hours for the pill to kick in.
Thanks for your reply. Very helpful. My symptons are a feeling like someone has a blow torch to the bottom of my feet and some disconfort in my calfs area. This is at night. During the day just very senitive bottoms of my feet which slows my walking. Did you get a reason for your NP? I have been to at least 10 doctors checking everything out but no luck.
Also to get 800 per per dose are your pills 200mg each?
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@johnbishop Thanks for sending the link, but my question was ALA studies pertaining to idiopathic neuropathy, since that was the original question. You can see that studies done are primarily related to chemo-induced and diabetic neuropathies, not idiopathic. https://scholar.google.com/scholar?hl=en&as_sdt=0%2C24&as_ylo=2021&q=idiopathic+neuropathy+and+alpha+lipoic+acid&btnG=
I'm thinking there probably are no studies for idiopathic since it means they don't know the cause so how can there be a study...just my right brain thinking 🙂 Here's some generic really good information about Alpha Lipoic Acid and how it works at a cellular level to help many different conditions by The Linus Pauling Institute at Oregon State University.
-- Alpha Lipoic Acid: http://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid
-- Research seeks to identify the mode of action of two age-essential micronutrients, lipoic acid (LA) and acetyl-L-carnitine (ALCAR): https://lpi.oregonstate.edu/research/hap/aging-stress-response-and-mitochondrial-decay
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2 ReactionsI was getting ready to order more A lipoic acid when i came across this thread. I see mine by Nature's Pure is a combo of R and S lipoic acid. I also take Vitamins. D3 and K2. L carnitine made me vomit 2 days in a row so I don't take it.
I had some neuropathy in my feet before I started chemo, but it didn't interfere with my life. After receiving Taxol, my feet became very numb and I had to stop driving. Some feeling has come back to my feet and I was able to make an 8 mile drive to a shopping center. Going was no problem; after the joy of being in a shopping center again and tromping around, my feet became numb and the drive home wasn't much fun. I've never had painful feet, just numb. I do believe my feet are better and I would recommend trying the 3 supplements I mentioned. You don't need a fancy brand. I also take phosphatidyl serine. It makes me feel relaxed. If you notice the ads for Prevagin and other brain supplements, the main ingredient is phosphatidyl serine and it's much easier and cheaper to buy a bottle of phosphatidyl serine on Amazon. I take 600mg of gabapentin a day. I've cut back from 900 a day.
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2 ReactionsYour right about Gabapenten
Does Gabapenten work fo anybody? I take 300 in the morning and 900 at night. Does not seam to do anything.
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2 ReactionsWhat is the supplement to improve urination? Thanks
I started off slow with Gabapentin about 18 months ago and now take 1800mg, 300mg in am, 600 in pm & 900 before bed. At this point, I don't want to stop for fear of the pain getting worse. The max dose for seizures is 3600mg. It is also prescribed for Restless Leg, which I think often accompanies the misery of PN. Does it work? Who knows. I have gained 8 lbs which at 72, will be difficult to shed. Back to strict Keto. People tell you to exercise, but just doing light housework & making myself presentable every day can be excruciating. This disease robs you of even the most simple comfort & pleasure.
Have you tried Lyrica?
Over about 4 months, I started at lower doses of Gabapentin until we seemed to hit a sweet spot at 800mg 3x daily. The benefits I receive from it are reduced intolerance to cold/heat in hands and feet reduction of the deep nerve pain associated with my PN. It might help some with the tingling, but nothing for numbness, but they aren’t painful. I am fortunate I don’t have side effects. My only worry had been when I let a dose go by and pain sets in, it usually takes about 2 hours for the pill to kick in.
Hey Debbie,
Thanks for your reply. Very helpful. My symptons are a feeling like someone has a blow torch to the bottom of my feet and some disconfort in my calfs area. This is at night. During the day just very senitive bottoms of my feet which slows my walking. Did you get a reason for your NP? I have been to at least 10 doctors checking everything out but no luck.
Also to get 800 per per dose are your pills 200mg each?
Thanks,
John
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