I too have found estradiol cream to be very expensive. I only use 3 drugs (I consider myself lucky in that department) but the ones I use are expensive. My new Urogyno suggested a compounding pharmacy for my prescription now, which cuts the estradiol cream cost in half! Maybe try that? (One of my other drugs are Restassis eye drops.....I picked my prescription plan to cover those because not all plans do..... and they were $300 per month! With a Single Care coupon I'm getting them for $30). It is a 'pink tax'.......less care, research and hiked prices taking advantage of women, probably because so much has traditionally been managed by men, sigh. No offense to men in general.......just the way the system was built. We just need to raise the questions over and over in hopes of getting things to improve. Hugs.