Prostate concerns high PSA numbers

Posted by rpeecher @rpeecher, Mar 31, 2023

PSA numbers 1/20/22 3.47 PSA
1/6/23 5.21 PSA
1/30/23 5.59 PSA
Had office exam, large prostate.
Had MRI and results below:

Prostate gland dimensions: 4.6 x 3.5 x 3.8 cm
Prostate volume:32.0 mL
PSA density: 0.17
There is moderate hypertrophy of the transition zone with mild hypertrophy of the median lobe.

Lesion 1-PI-RADS 4
Focal T2 hypointense signal in the left anterior peripheral zone at base measuring 0.7 cm at the transition zone junction (7:16) with significant diffusion restriction and early preferential postcontrast enhancement.

Lesion 2-PI-RADS 4
Somewhat linear T2 hypointense signal in the left posterior lateral peripheral zone at apex with moderate diffusion restriction and minimal preferential postcontrast early arterial enhancement (9:17) measuring 0.6 cm.

Lesion 3-PI-RADS 3
Mild T2 hypointense somewhat wedge-shaped signal in the left posterior medial peripheral zone at base to mid gland with mild obstruction, without significant postcontrast enhancement measuring approximately 0.7 cm.

Additional scattered linear and wedge-shaped T2 hypointense signal foci within the bilateral peripheral zones do not demonstrate diffusion restriction and are likely inflammatory in etiology. (PI-RADS 2).

Scheduled for a transrectal biopsy, since Kaiser (carrier in Oregon) does not do transperineally biopsy.

Any input on my numbers or if this is the correct direction to go? I'm at a lost

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I think that a biopsy is absolutely necessary at a first rate cancer facility and then treatment at a top notch facility if necessary and possible. In my experience, kaiser is not an aggressive cancer facility but they might partner with such a facility

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Echo hbp: Biopsy necessary to diagnose cancer.
My biopsy was transrectal with no residual biopsy related issues, performed at a teaching institution local to me.
With aggressive cancer results, I received a 2d opinion (and surgery) at a center of excellence, fortunately located only a 90 min drive away.
My input is to have the biopsy ASAP, and then you will have the information needed to make the next decision(s).
Wishing you and all the best.

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I had a TRUS biopsy with spinal anesthesia, had a cathether for overnight, got discharged the next day. Discomfort for maybe a day or two.

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Would that be a targeted or fusion biopsy?

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Get a biopsy ! My guys was 180 his PSA ! It’s supposee to be 1-7 😊

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I'm 74... prostate psa 16..had biopsy..3+4..6 nodes..wish I would never had biopsy.. been through hell last 2 years.. depends on your age..I didn't want a long life..just quality..it's never off my mind .. good luck

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@booterbaugh

I'm 74... prostate psa 16..had biopsy..3+4..6 nodes..wish I would never had biopsy.. been through hell last 2 years.. depends on your age..I didn't want a long life..just quality..it's never off my mind .. good luck

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At 75 with PSA OF 83.4, I spent more time worrying about biopsy than recovering . Not a big deal. My results sucked but doing OK now. 1 year later PSA is 0.1. Not cured but have hope for 10+yrs.
Best of luck.

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@spryguy

At 75 with PSA OF 83.4, I spent more time worrying about biopsy than recovering . Not a big deal. My results sucked but doing OK now. 1 year later PSA is 0.1. Not cured but have hope for 10+yrs.
Best of luck.

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Good luck with your PC. My dad's PSA number was over 1000. I was incredulous until his oncologist sent me the document (dad was 1000 miles away but I had medical power of attorney). The document showed 1050. He had such bad dementia that he couldn't describe his symptoms but did live to be 90. My brother and I are now both battling it but the technology has certainly advanced in the last 20 years. Better living through chemistry.

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@kchris5174

Good luck with your PC. My dad's PSA number was over 1000. I was incredulous until his oncologist sent me the document (dad was 1000 miles away but I had medical power of attorney). The document showed 1050. He had such bad dementia that he couldn't describe his symptoms but did live to be 90. My brother and I are now both battling it but the technology has certainly advanced in the last 20 years. Better living through chemistry.

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Thanks for your response. What a journey your family is experiencing.
Let's hope science keeps coming up with new and better treatments.
Best of luck.

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@hbp

I think that a biopsy is absolutely necessary at a first rate cancer facility and then treatment at a top notch facility if necessary and possible. In my experience, kaiser is not an aggressive cancer facility but they might partner with such a facility

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I disagree with your comment regarding Kaiser. My treatment for prostate cancer performed by Kaiser urologists and surgeon (RALP in August 2022) in the SF Bay Area has been excellent. I do suggest that the patient does his research regarding caregiver selection to find the best care/treatment for the need.

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