Hi Robert,
My hematologist gave me an information sheet on HU. It said to take half hour before or after eating with a full glass of water. Also, it is very important to drink minimum of 64 ounces of fluid daily to flush the toxic effect.

Since 450 or less is normal you were close to normal. From what I have read platelets can jump up and down by what is happening in your body.

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Eileen