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Hydroxyurea side effects lessen over time?

Blood Cancers & Disorders | Last Active: Mar 31, 2023 | Replies (36)

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@robert3861

Wow it seems HU really works good for you at a low dose. It seems to not work as well for me I have been taking this med for probably over 2-3 months I started with my platelets at 602 and they are at 478 as of Tuesdays blood work. I told doctor my platelets are not life threating enough to raise HU up because I don't want to deal with side effects of this med. Let me ask you this I take my Pill right after Supper full stomach around 6:30 pm. When do you take it ,and do you take it on full stomach or empty ?

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Replies to "Wow it seems HU really works good for you at a low dose. It seems to..."

First let me say that as long as my platelets are 600 or under my doctor says that’s fine Hematocrit at 45 or lower. I have taken them at night in the beginning with no food and now I switched to mornings (only because I was told I can drink alcohol moderately and enjoy an occasional glass of wine and didn’t want to take the pill at the same time) it did take about two weeks for my stomach to adjust but didn’t matter in my case with or without food.

Hi Robert,
My hematologist gave me an information sheet on HU. It said to take half hour before or after eating with a full glass of water. Also, it is very important to drink minimum of 64 ounces of fluid daily to flush the toxic effect.

Since 450 or less is normal you were close to normal. From what I have read platelets can jump up and down by what is happening in your body.

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Eileen