I have a similar story. I have been NED for 10 months. Now my markers are going up over the past 16 weeks. CA19-9 is 612--previous in the mid-30s. I wondered if we should treat right away, but there are no tumors on the scan, and he does not believe in treating based on numbers alone. He is extremely qualified and experienced so I believe him. He says the only reasons to treat with chemotherapy is if chemo will either 1) make you feel better or 2) make you live longer. And in my case, neither is true. Like your husband, I feel wonderful with no problems or symptoms. According to the research, he says that early chemo (with nothing solid to treat) would only harm my quality of life and would not increase my longevity. I hope this is helpful. Beth