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What is the recommended treatment after 6 Pluvicto doses?

Prostate Cancer | Last Active: Dec 19, 2023 | Replies (27)
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@colleenyoung

@donalan, I'm tagging fellow members like @leebeth @suwairi @patgwenn @ncoic @bburgess1 @royalbee @bamaples @bamaples @dlylecpa @robert570 who have experience with Pluvicto (Lu 177) and have shared in this related discussion:
– Anyone on Pluvicto (Lu 177), a new drug for prostate cancer? https://connect.mayoclinic.org/discussion/any-one-on-pluvecto-a-relatively-new-drug/

You ask a great question. After 6 doses of Pluvicto, what next for maintenance treatment? Some members have just started Pluvicto while others have had several doses or completed it. I hope you'll share what your oncologists have suggested.

Donalan, back to you. What has been recommended for you next?

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Replies to "@donalan, I'm tagging fellow members like @leebeth @suwairi @patgwenn @ncoic @bburgess1 @royalbee @bamaples @bamaples @dlylecpa @robert570..."
foamhand | @foamhand | Sep 8, 2023

Starting Pluvicto on Sept 26th. Asked my Oncologist what's after that? He said Pluvicto is currently the last line of BSoC. (Best Standard of Care)

After that, he would consider Cabazitaxel again (which has already failed by itself) with adding Carboplatin.

Then there is the Talapro-2 study drug combo (My experimental oncologist is Dr. Neeraj Agarwal at Huntsman Cancer Institute in SLC UT, who co-directed the Talapro-2 study. (I'm so lucky to have direct access to a solid tumor research professor!) The Talapro-2 study is a combination of drugs that best target advanced Prostate Cancer that has defective BRCA repair genes. I DO NOT have the genetic defect this is directed at, but they are seeing some benefit in people without the defective repair genes, although not nearly as pronounced as those with the defective gene.

After that, any Clinical Trials that I may qualify for according to my primary oncologist are all that's left before Hospice care. Looks like the toolbox is getting low.

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