My dad (76) was diagnosed with stage iv pancreatic cancer with several liver mets. Did 5 cycles of FOLFIRINOX 5-FU. Progression scan this week showed mix results. Seems the pancreatic tumor was demonstrating some dying cells, some liver Mets grew while some decreased. Our Dr. Recommended switching to abraxane/gemcitabine given his cancer symptoms were not really improving. He got his first round this week- he has been experiencing the worst pain he has yet after this treatment. I am worried that we may have not made the best decision and he is reluctant to get a second opinion. Can anyone share their experience of switching chemo regimens? How long does it usually take to notice a difference? Any advice is appreciated- at such a loss right now. There is so much information to read and each case is so different- but hearing other stage iv stories give me a clearer picture. Thank you all in advance.