Hello, I’m taking it for about two months now 500mg daily. I find that it lowers my platelets substantially, but my hematocrit usually goes down with the phlebotomies. I did read that HU can cause joint pain but also that it can take time for your body to adjust to the meds. Not sure how long that is but I would talk to your doctor. I have the tingling on my tongue, sensitive gums and some small brown spots on my skin. Dermatologist said they are cosmetic and not dangerous so I will keep taking it for now. There is only one other drug for PV if this is not tolerated, and it has more side effects and is much more expensive. Speak with your doctor and feel better.