Hi Jackt00,

Welcome to the site,

Given the fact you are taking another chemo med, I would like to suggest you ask your hematologist if you could slowly taking Hydroxyurea. It seems some only take it three days a week or every other day and adjust up as needed.

Remember to drink minimum of 64 ounces of fluid taking HU. I do not even touch the capsule. I slide it out to a small lid. I wet my lips and swirl water around my mouth and I slide the it into my mouth with glass of water so all are lubricated. This helps prevent mouth sores.

I am 78 JAK2 and have had headache issues taking HU. My hematologist lowered me to 500 mg every other day and it was working nicely, My goal is 450 or lower for platelets. We were in the process of closing up a house in one state and moving. With the stress my headaches greatly increased and hematologist let me go off HU for a month. I see her soon and I will be back on HU.

Best wishes, Eileen