I have post essential thrombocytosis Myelofibrosis . I had thrombocytosis for 10 years and now for the last 3 years I have Myelofibrosis . I take Jakafi (ruxolitinib). I am 71. There is no cure as of yet . Jakafi helps keep the red blood platelets under control but does not control my white cell count which is sometimes high. I have had minimal side effects such as fatigue. But recently my spleen is slightly enlarged and slightly tilted. I am slightly fatigued . The worst side effects have been recuring non melinoma skin cancer with six Mohs surgeries and more to come. Another minor side effect is weight gain . So it is important to eat healthy and be active . Meditation is also helpful . Be positive and grateful for each day and surround yourself with loving family and friends .