I've been on HU since April 2021. The first year on HU I had gut side effects. Finally after a year, the gut side effects subsided. I still have bone pain in shins and toes at night, but Dr said not a symptom of ET or HU ??? I had the pain before HU and I still have pain, but the pain seemed to start when my platelet count started rising over a 3 year period before I was diagnosed. I also have numbness in my hands when I wake in the morning.