I began taking 500 daily, after my first four weekly phlebotomies and taking the HU my platelets dropped from 777 to just over 200. He stopped the HU. Within 3 weeks platelets jumped back over 600 w/o phlebotomy. Put me back on HU a week ago. 5 days on, two off. Labs are due this week again. From what I’m reading, that’s a low dose. If monthly phlebotomies get me the right numbers w/out the meds, I’d prefer that, but it’s too soon in the game and he wants me on the meds.