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Hydroxyurea side effects lessen over time?

Blood Cancers & Disorders | Last Active: Mar 31, 2023 | Replies (36)

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@dale1k

68 male, diagnosed just under 2 years ago with PV.. I can’t comment on menopause but have been on hydroxy urea since April 2021.. You didn’t mention how many pills you are taking.. In my case, I started at 7000 Mg per week and raised to 8500 mg per week where I am currently… I go for monthly blood tests and numbers have been good.. Your body will let you know over time how the HU may or may not impact you… Some people can’t tolerate HU at all and yet others have little or no side effects … So far, I fall into the second category… Currently, I can’t definitively point to any side effects from the HU.. Will that change over time?? I have no
clue.. Despite feeling really good, I always hold my breath for the monthly lab results.. Best to you..

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I began taking 500 daily, after my first four weekly phlebotomies and taking the HU my platelets dropped from 777 to just over 200. He stopped the HU. Within 3 weeks platelets jumped back over 600 w/o phlebotomy. Put me back on HU a week ago. 5 days on, two off. Labs are due this week again. From what I’m reading, that’s a low dose. If monthly phlebotomies get me the right numbers w/out the meds, I’d prefer that, but it’s too soon in the game and he wants me on the meds.