I was just diagnosed with PV in January. Same routine. Weekly phlebotomies and then bi weekly labs and put on hydroxyurea b/c my platelets jumped over 600 after 4-5 weeks. I was wondering the same thing about dropping the drug and doing monthly phlebotomy? I am 56 and plan on asking once I have a regular “schedule” for the phlebotomies. I have very sensitive gums, swollen like small sores and DID not have them until on the drug. I was told to wait and see if my body should adjust? Also after just a few weeks, I have small brown spots on my skin which is also related to this med. Dermatologist said they are not dangerous, just cosmetic.