@clefever33, I believe your question was directed at @danab, who I'm tagging here to make sure he sees your posts and can give an update on his wife.

I'm sorry to hear that your friend initially responded well to transfusions. How is she doing now?

Hi Cindy, Sorry i didn't see your reply until Colleen helped out. We are still having bouts of weakness, but its unusual that She can head out and walk up to 4 miles but come home and have periods where climbing the stairs is a challenge. Since then, Iron seems ok at the moment and in the search to find out what the cause is her cardiologist has put in a loop recorder and so far nothing has shown an issue. The last time she had blood work everything looked fine. So even with the periods of weakness its not totally incapacitating like the time I wrote about initially.
Is your friend under the care of a hematologist? The one my wife sees a Oncologist/Hematologist a cancer center, I guess its a similar profession for Doctors who specialize in blood disorders.