I have been on Actemra for over a year for Giant Cell Arterites (sp?). It is an amazing drug. Before it, I couldn't walk to the mail box. Dr. put me on Prednisone for 6 months prior to starting the Actemra. It took over where the Prednisone left off and eliminated all of the prednisone side effects. I also have minor thrombocytopenia (bleeding disorder) and haven't seen any problems using the two drugs. I also take baby aspirin, cholesterol, and blood pressure meds so Actemra could react badly with them--but it hasn't seemed to for over a year. However, I am now starting to get a reaction, minor swelling at the injection site and sometimes itchy hives a couple days after injection. A Zyrtec seems to keep this under control. Dr prescribed one Zyrtec the day before, the day of, and the day after the injection. I seem to be able to use less taking it when I need it. The Actemra has reduced my deep artery swelling to minimal and, depending on the next MRI results it is expected I might be able to reduce my weekly shot to bi weekly and then none at all. I am 80 yrs old. Of Swedish and German/Dutch descent.