Like someone above mentioned, you need to get your daughter to the best hematologist / oncologist you can find, preferably at a major medical center. I was diagnosed in early 2022 after a rheumatologist did some blood work for joint pain that I've been having for a few years. I consulted a friend who is a retired oncologist and they told me that MGUS is rare and not to fool around with local docs because they don't see MGUS enough to really know what they are doing. I now have a great doc who did all of the initial testing and checks my bloodwork every 3 to 4 months. He has also been great about explaining everything to me. I am stable for now, but I am still battling the extremity joint pain. I am super-sensitive to many medicines used to treat the pain and one even caused my airways to inflame causing major breathing issues; although I don't know if that had anything to do with the MGUS.

I don't know how old your daughter is, but I was told that most people don't develop MGUS until their 70's or older. And, that they usually die of other causes before developing into smoldering or full-blown multiple myeloma. Those of us who are younger have a higher chance of actually developing into the full myeloma disease, although it may take 15 or 20 years for our cells to reach the numbers where they actually treat the disease. Monitoring is so important because we don't want to have any lag once our cells begin to spike into the treatment range.

My oncologist always encourages me to get my vaccinations. I doubt he would be doing that if there was a correlation between the vaccines and the disease. At one time, my Ig numbers were VERY low and my pulmonologist was extremely worried about me catching anything, but they have since come up a bit. My numbers which are not great by any means, were still up after I got my last bivalent Covid vaccine.

I wish your daughter all the best. I'm puzzled that they are pushing treatment at this stage. I would get a third opinion, because I'm not sure why the University would want to treat at this stage. Then again, I'm not a doctor. Have they checked for bone lesions?