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Gleason 9: ADT before radiation

Prostate Cancer | Last Active: May 14, 2023 | Replies (42)

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@sailorman2003

That's a well reasoned approach and one I plane to follow unless some new evidence comes to light. There are still choices and I am curious what you decided:
ADT yes or no and how long if yes?
What type of radiation? Proton Beam Therapy? Stereotactic radio surgery?
From what I read about ADT, it would turn me from a very active 83 year old, to an old man in a year. What do you think?

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Replies to "That's a well reasoned approach and one I plane to follow unless some new evidence comes..."

I've had a similar experience to @drj . Except my Radiation Oncologist did answer the question of numbers using ADT vs not using it.

My history is a little different though, RP followed by "biochemical recurrence", maybe? My PSA was high enough second time around to meet the clinical definition of BCR but we decided to be aggressive and treat with radiation and ADT. I'm on Orgovyx which is a newer oral version. I've never taken Lupron so I can't compare it, but, it stinks as well. All the same side effects. I've been on it for a full year. I'm 61.

My RO told me that, in my situation, ADT provided 3%-5% better outcomes. That's pretty much a quote. You'll be able to locate other numbers in various studies. My surgeon who is sort of the "quarterback" for the treatment wants me on it for 2 years. The RO (same practice) says 6 mos is plenty. The RO essentially says the reason for the ADT during radiation is that it weakens the cancer so that the radiation is more effective. I asked if it actually killed cancer cells and he tells me "no."

I research as best as I can, I can't find anything that claims ADT kills cancer cells.
Harvard Medical "Hormone therapy, formally known as androgen deprivation therapy (ADT), deprives prostate cancer cells of testosterone, which they need in order to grow and spread."

Next appointment at the surgeon, (quarterly post PSA test visit) I ask why two years? He tells me we want to kill any cancer cells that might be left in my body. Ya can't make this stuff up. These guys are all in the same medical group.

My next blood test is going to be a full panel test, we'll see what else the ADT is doing to my system and likely make a decision then. If it isn't doing too much damage to liver, sugar etc.. I may gut it out.

I have two friends who had PCa years ago, had radiation without ADT and are doing fine. Who can tell? One was a Gleason 6 the other 7 like myself.

My feeble brain at this point goes to this....
My current psa is