Hi... I use the estrogen cream twice a week. I want to mention that using the cream is supposed to create a healthier, stronger, vaginal wall. Maybe that would help with the painful intercourse? I absolutely have no breast pain or elevated blood pressure. Can't talk to weight gain... I have had three surgeries in three months, two of which were colon related. I lost 10 pounds, but in the last couple weeks, I have gained 5 back. I truly don't believe the cream had anything to do with my weight, because during the colon crisis, I was on a strict low fiber diet for 8 weeks. I had a few weeks of broth and jello during that time, which caused the 10 weight loss, not the cream.