Daralutimide, or others and even chemo PL 111 if qualify

My oncologist started me Xtandi beginning of year after being on biclumate for about nine months. I am Stage IV and have been receiving lupron injections every 12 weeks as well as Zytiga infusions since APC diagnosis. Prior to this I was receiving lupron/elgard under an Urologist care intermittently for approaching five years.
I've learned several things while under this menu; the tolerance for the drugs is individualistic and it gets better over time
The Xtandi makes me a bit goofy shortly after injection, but that passes in maybe about an hour. I take them after breakfast and that helps for me. Also, I kindof like goofy
I do get fatigued in the afternoon, but an afternoon siesta handles that. I would suggest AM injestion with an early PM nap, so as to be ready for nite-nite whenever your regular sleep time is.
I have a hard times staying up through the late night talk shows, lucky to get through the monologue.
The results on just Xtandi have just been outstanding, it's truly a wonder drug for us APC patients. At my last oncologist consult, just prior to poke & pump I offered to do an Irish jig for General Bruce (my nick name) & internist. PSA dropped to 0
30, from 0.70 two weeks prior and 3.3 10 weeks prior to that.
The General had me get a bone scan (not fun) before latest consult and the radiologist read was several areas visible in cartoon from a year prior leading to APC diagnosis had lapsed to non-detect. I was flummoxed, hence the offer to dance. I had no idea the metasticized cancer would do that, I only wish they would apply some stats to it, rather just eyeballing it. The 1st scan was termed a Chtistmas tree, but in my case a few lights have burned out - hurrah@
I am continuing to lead an active life style, albeit the type of activities I have shifted to low impact, weight bearing, just like our oesteo sisters. Lot of walking and dancing when I hear live music which stirs my soul. Gettimg some aquatherapy from some PT folks which I like. Have also been through a CBT course & consult as an alternative to using Rx narcotics for pain management.
It's working for me, enough so I am about 2/3rds way through a x-country train trip now
Can't say enough good Xtandi driving down my baseline. Thankful that Pfizer adjusted their pricing strategy, with a little encouragement from Congress, to make it available to more than just wealthy APC patients. The US taxpayers paid for the research for this break-through drug.
Peace & tranquity to all my APC brothers, happy to tweet experiences and tks to Mayo Clinic for providing the forum to do so.