I believe that no two peoples cases are the same and as the JAK2 mutation is rare, doctors are treating patients on an as needed basis. In my case, my platelet count never reached 700. However, I've been seen at the same medical practice for my entire adult life (in my 60's). My doctors felt that the steady rise (platelet count was always well within normal range) was enough cause for concern that they performed the DNA analyses. Immediately after the positve JAK2 test result I was prescribed 500 mg Hydrea daily along with a low dose aspirin daily. Everyone here will have a sightly different journey...you're not missing anything, you're just on your own journey. I hope it's a long and uneventful one! 😉