Trikafta has definitely improved the bronchiectasis, and my infections have been less frequent. I've been hospitalized twice for lung infections since starting it almost two years ago, but that is a great improvement over what I was going through before. I've not been hospitalized for an infection for a year now. One of the nicest improvements is that I can actually lie down to go to sleep at night without a 30-40 minute spell of coughing stuff up before falling asleep. I'm also no longer using a SmartVest (although I had to stop using that because it was interfering with my pacemaker). My lung function did show a slight improvement at my last checkup in early January. As for your other question: I have never had to deal with MAC; I've had other infections to deal with, primarily Achromabacter.