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MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio

Blood Cancers & Disorders | Last Active: Jan 1 2:01am | Replies (172)

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@lipstickonmycollar

Hello everyone. I was diagnosed with MGUS a few years ago. After a while, MGUS no longer showed in my blood work. I had heard that it couldn't go away but it isn't showing currently. But I am still concerned about the way that I feel physically. I am sick daily. Very sick. And this is coming from a person who has had a few kidney surgeries and some other health issues. Also, I have seen real sickness when my mother died of cancer. I also watched my mother, and aunt, and a cousin die of cancer as well. So, if I say I'm sick, I don't mean the flu or a head cold.
I continue to see a hematologist. She always says that everything is fine. But something is not right. I have attached a copy of some of my last test results and I'm hoping that someone can make sense of it. I'm no looking to be sick. But I am looking to feel better and hopefully finding out the root cause of my illness. Oh yes, one more thing is that my parathyroid levels are off but according to my nephrologist something is triggering it. It's not the kind of thing that removing thyroids will fix. Help!

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Replies to "Hello everyone. I was diagnosed with MGUS a few years ago. After a while, MGUS no..."

Lori, Volunteer Mentor | @loribmt | Feb 11, 2023

Hi @lipstickonmycollar. Love the @name! But not liking that you’re feeling so ill on a daily basis.
Members in the forum can’t interpret results of medical tests, diagnose or offer treatment. But we can use our experience to help each other find answers.

Your blood numbers on the CBC are all in the normal range but your kidney GFR number is quite diminished. You’re seeing a nephrologist so I’m expecting they are aware of the decrease in function and it’s not the cause of your feeling so poorly…though it maybe collateral damage of whatever is causing your illness.

However, Kappa/Lambda light chain ratio is quite elevated. Kappa/Lambda free light chain serum test is a blood test that checks for high levels of certain proteins in your blood. Elevated free light chains might mean you have a plasma cell disorder. Along with the Immunoglobulin G also being higher than normal, this really warrants more action from your hematologist.
I don’t mean to alarm you but this can indicate a more serious transition from MGUS. You are right, MGUS doesn’t go away and can develop into other conditions such as Multiple Myeloma. If your hematologist is cavalier about these light chain results, saying ‘you’re fine’ when you are feeling so ill, it’s time to get another opinion.