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Anyone Heard of Pirenzepine for Small Fiber Neuropathy?

Neuropathy | Last Active: Oct 19 5:54am | Replies (107)

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@lupusgirl

I crush up 150 mg which is about 4%. Mix it with 70% DMSO gel, which is available on Amazon. You don't need a lot of the gel. Just two squirts.Add a couple of drops of water. It dries like water and is not greasy at all.
I've been using the foot and calf application plus I take 25 mg a day. It's been about a week and a half since I started it. Haven't noticed anything yet but wouldn't expect to because nerve damage only reverses 1 mm a day. If I notice anything I promise I will report back.

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Replies to "I crush up 150 mg which is about 4%. Mix it with 70% DMSO gel, which..."

Hi,
I just ordered the capsules to try and make a topical. Did this work for you as a topical? I'm a little nervous to take it orally but I'm very interested to know how this worked for you now that time has gone by. Thanks so much!

You say "I crush up 150mg which is about 4%." the 150mg of pirenzepine is 4% of what? The way I read it is you need a 4% solution of pirenzepine in DMSO. To get the proper 4% mixture you need to mix 150 mg of pirenzepine with a specific amount of DMSO, otherwise the 4% ratio is not correct. How much DMSO are you mixing with the 150mg of pirenzepine?