I have neuropathy in my feet that extend up to my calves. I also was getting cramps at night that were excruciatingly painful. My rheumatologist suggested that I take Magnesium oxide 500mg, but warned me that given that I’m a small person, I may experience diarrhea as a side effect, in which case I should cut the tablet in half. I now take 250 mg at bedtime and I no longer experience cramps. Perhaps you can try and see if it works for you. Best wishes.