My experience with Trikafta has been very positive. Before it, I would routinely have to go through 30 (sometimes 45) minutes of coughing, etc., once I lay down to go to sleep. And that was just one effect. Overall, it has made the ordeal of getting junk out of my lungs much, much easier. When I started it, I went through a few days of "purging" when I was bringing up all kinds of junk from my lungs, but things settled down after the purge.