The MRI guided biopsy is the best route, IMHO. That is what I did. I watched it as they did the biopsy and by using this method they can pinpoint the exact places from which to choose. It was not as uncomfortable as it seems. The numbing shot isn't pleasant, but the process was painless. I just felt pressure as they punched their holes. So glad I did it this way. 11 years ago, before the MRI guided, my biopsies (12 then 24 cores) were negative. With the MRI in the same general areas as the previous biopsies showed cancer. Glad you are using this technique. Stay strong, focused, proactive and resolute.