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@edroz01

I’m a 76 year old woman who has had PD for about two years now. The most problematic issues I’ve experienced are fatigue and brain fog. I also have some tremors. I’ve tried Sinemet for months, but it seemed to cause more problems (e.g., dyskinesia) than it helped with. I’ve been taking LDN for two months now, so still assessing that. I’ve worked closely with my primary care physician and a neurologist.
I recently started taking Rasagiline.

My questions are:
1 - Has anyone found anything that has worked to reduce fatigue or brain fog?
2 - Has anyone tried LDN, and if so, what results have you experienced?
3 - Does anyone have positive experiences with any alternatives to Sinemet such as Rasagiline?
4 - Has anyone tried HIFU/MRgFUS for PD Tremors?
5 - Has anyone tried the experimental glove treatment for tremors?

Thank you!

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Replies to "I’m a 76 year old woman who has had PD for about two years now. The..."

Hello @edroz01 and welcome to Mayo Clinic Connect. I think it is great you've joined to learn from others with regard to their Parkinson's journey. In order to better connect you with members, you will see that I have moved your post into the welcome discussion, which you can find here:
- Living with Parkinson's Disease - Meet others & come say hi: https://connect.mayoclinic.org/discussion/living-with-parkinsons-disease-meet-others-come-say-hi/

Members like @rwinney @patriciajean @1died2x and @hopeful33250 may be able to come in and share what they have learned with you.

Which treatments are you leaning toward?

@edroz01 Hi, hope you're well today.

My fatigue was mainly due to RLS and Sinemet worked but during the wearing-off period I couldn't rest. My sleep was interrupted from about 2-4 AM every morning when I'd have to take another dose and wait for it to take effect. I found relief with the Neupro patch, which is a dopamine agonist and may be less likely to cause dyskinesia. Since I get a continuous dose of medicine, my sleep is not interrupted and I feel a lot less fatigue and brain fog.

In regard to tremors, I'm not aware of anything that eliminates them. Both Sinemet and Neupro decreased my tremors significantly but neither got rid of them entirely.

Hope you can find something that helps with your most troublesome symptoms.

Take care!

I am a 74 year old Male. Just had MRGFUS on Oct,
. 29th. DR. Sani at Rush Chicago was the neurosurgeon. I had a left hand resting tremor, tremor dominant Parkinsons. Long story short I tried every medication in every combination for tremor and nothing worked. After two years the neurologist I was seeing put up his hand and recommended I go to a teaching hospital neuro. Working with Dr. Gill for awhile she referred me to Rush's MRGFUS neurosurgeon, after a tele visit There are a few more steps to see if you qualify. My tremor stopped cold at end of procedure. I have a few expected side effects that should clear up in 3-6 months, such as a little numbness in my lips and tongue and a little gait disturbance when I walk but as an avid exerciser I have already been using my treadmill 30 minutes a day. My side effects are pretty minor I made a short story long but there was a lot to squeeze in. Good Luck