@gmichelle There is no clearcut evidence that it is always linked, but some people do experience low iron and anemia with MGUS. In my own experience, there are contributing factors with other health issues, and altogether, it created anemia. That said, it is my opinion only, that the whole person must be taken into account, not just one single thing. I advanced from MGUS to Smoldering Myeloma to Multiple Myeloma in short order, which was truly unusual. Coupled with end-stage kidney disease and, well, it was a perfect storm of things happening. My kidney disease is not related to MGUS or myeloma, but rather an ultra-rare autoimmune condition.

Here is what John Hopkins has to say about MGUS and anemia: https://www.hopkinsmedicine.org/health/conditions-and-diseases/monoclonal-gammopathies
Ginger

I had low iron in 10s for 15 years, oral iron always brought it back up. PCP didn’t want me to take iron all the time. After covid vaccination it did not go back up with 5 iron infusions. PCP suggested hematologist and I was diagnosed with Waldenstrom’s Macroglobulemia. Did vaccination turn lymphoma on??