Hi @brooks7987, welcome. I moved your question about HU (hydroxyurea) and interferon to this existing discussion:
- Polycythemia Vera: Just been diagnosed https://connect.mayoclinic.org/discussion/polycythemia-vera-1/

I did this so you can read past posts and connect easily with fellow PV members like @lindaw123 @kibbykyle @learnandlive @randles14.

You may also be interested in these related discussions:
- How do You Manage Side Effects Of Hydrea or Hydroxyurea for ET? https://connect.mayoclinic.org/discussion/side-effects-of-hydroxyurea-et/
- When is hydroxurea usually added to treat polycythemia vera (PV)? https://connect.mayoclinic.org/discussion/hydroxurea/

Have you discussed your concerns about skin cancer risk and your husband's active outdoor lifestyle with his doctor?