I was diagnosed PV in April ‘22, with JAK2 gene. Bloodlettings and Hydroxurea were prescribed. The former improved a high red spots in different parts of my face, the latter my headaches and odd & painful sensations in my legs. Did nothing for fatigue and made me very nauseous. Overall not very effective so was switched to Jakafi 10 mg. This improved platelets and blood count more effectively but fatigue remained as well as leg sensations. Then platelets started to rise again and switched to 20mg. Overnight the fatigue seemed to have gone and the sensations in legs are a lot less…. Now my blood tests are only about the platelets. 🥹