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Anyone had success regaining muscle strength with low testosterone?
Prostate Cancer | Last Active: Nov 14, 2025 | Replies (92)Comment receiving replies
I was on Lupron for 12 months and received my last six-month shot in June 2022. I underwent proton radiation treatment in March/April 2022. My PSA dropped from 45 pre-Lupron and radiation to undetectable in November 2022.
With my doctor's agreement, I did not receive another Lupron shot in December 2022 because I wanted to build up muscle mass for a long-planned four-day hike to Machu Picchu in May 2023.
I continued daily exercises and hikes throughout my treatment, but I am conscious that my strength and endurance have dropped significantly. I'm currently working with a personal trainer, but I still feel much less strength on long uphill sections of my daily hike. I'm really concerned that I may not have the leg strength to complete my fairly demanding four-day hike in May.
I'd love to hear others' advice on how long it takes to rebuild muscle mass after the effects of Lupron have moved out of the system.
Replies to "I was on Lupron for 12 months and received my last six-month shot in June 2022...."
I'm 64 now, I was diagnosed with prostate cancer in 2019 (with 4+3) 7 gleason score. 12 cores taken and 8 with low grade and 4 with high grade cancer. Chose Brachytherapy due to my age and cancer was within the prostate. Pre surgery my PSA was 10.7, Post surgery is was 1. One year post surgery, my PSA started to climb. Tested every 3 months at 1.2, 1.4, 1.6, 2.0, 2.4, 2.8, 3.4, 4.2, 7.9. As it was continuing to climb, I was sent for a PSMA PET Scan. I was told the prostate was ok but the cancer cells had spread to my lower lymph nodes which was making the PSA rise. Prostate cancer is now Stage 4, and not curable. I was given 5 sessions of MSK Precise Radiation as well as two - 4 month shots of Lupron. I have just finished the 8 months of Lupron. I have gained about 30 lbs while on Lupron and look forward to dropping this weight now that the treatment is done. PSA and T are both not detectable on my latest test. Time will tell if this treatment will help long term. Muscle mass has dropped and strength especially low in my legs. And OMG - the hot flashes still suck!
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I am 67 and inject 1 ml every week to 10 days. What surprises me is they do not give you a testosterones test before prostate cancer treatment. I if you have had your prostate removed and your PSA is below .2 I think it would be pretty low risk for you
My original T test I came back at 520 and my Urologists thought that is just fine. I brought her copies of trials and studies that were done and she refused to even look at them so I found a new doctor.
I am glad you found TRT and it is working for you, I think it is worth the risk not to be fatigued all the time.