Hi @esperanzam The other medications used in the treatment of Essential Thrombocythemia are Anagrelide and Alpha interferon. The go-to first tier drug is Hydroxyurea.
If you’re having side effect with the HU, I’ve noticed other members in the forum have talked to their doctors about altered doses such as 3 days on 2 off or reduced dosages with lab monitoring. Have you talked to you hematologist about this option?

ET/CALR and aVWD. My platelets were nearly 2900. I now take 1500mg of HU 4 days a week, 1000 mg )n the other days. I also take 1mg of Anagralide daily. Sounds like a lot but it helps keep my platelets down under 1000 and trying to address the aVWD. Long process with weekly blood draw. Main side effects are fatigue and headaches. Have had issues with mouth sores but seem to have subsided.