My Dr discussed Hydro and Peg, but when I asked what she would do in my case, she said Peg because while Hydro absolutely brings down platelet levels, Peg has the additional benefit in some patients to prevent the ET from going into the more dangerous fibrotic mode of the disease. Of course no guarantees and many folks are on Hydro for life with no new progression. I did see that word mentioned a few times in my bone marrow biopsy (which my Dr said I do not have at this point) so maybe the fact that my platelet levels were rising so fast made me a better candidate for a more aggressive treatment. My levels went from 600 to 950 in four months. So after my first month on weekly Peg injections, I came down to 900...I'm taking that as a win as it stopped the creek from rising. We'll see next month!