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Estradiol levels with AI

Breast Cancer | Last Active: Feb 27 5:02pm | Replies (35)

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@windyshores

Again, if a dose is "effective," meaning it reduces estradiol below detectable levels, the side effects of bone loss or elevated cholesterol or whatever, would be the same I would think. The side effects are from estrogen suppression and estrogen is suppressed if the dose is effective. That is the whole point of the med.

In other words, I don't see any reason why a lower dose, if effective, would cause fewer side effects.

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Replies to "Again, if a dose is "effective," meaning it reduces estradiol below detectable levels, the side effects..."

I’m in agreement with you and I am grateful to have this med available to me; I am counting on it to be of great value for my 98/99% ER+. I feel safer taking it. What you say stands to reason and makes perfect sense. That said, the medical and research establishment is looking into lowest possible dose/effectiveness ratio. They mention the reason is because side effects account for significant non-compliance. This does make one wonder what is under consideration because, as you say, the side effects are BECAUSE of estrogen reduction… which is what is needed for treatment.