Had first treatment for 3 mos two years ago and felt no difference, but just started another round this week and will give it another try, since they have changed the protocol: added acetyl-l-carnitine to injection formula. The Sanexas company works closely with my clinic here in the Richmond area and will make adjustments as needed for individual cases. I have never taken any Rx, only supplements from naturopathic, ayurvedic and TCM medicine. Also use reflexology and walking several miles daily, which seems to help.