I'm JAK2 positive as well, and have had high platelets since my 30s. I'm now 64. Because my platelets are now near 1 million and my other blood counts are haywire, the oncologist is recommending, rather cavalierly in tone, HU. I have had visual migraines on an off all these decades, but otherwise am basically asymptomatic. I really don't want to start HU because I'm afraid I'll actually feel worse on it, and I'm horrified at the whole concept of chemo drugs and the trouble they may bring down the road. Seems so crude a method. (Is the devil I know better?) I have not had clots and so forth, but I'm still obviously in a high risk category, despite good cholesterol and blood pressure, long time vegetarian, walker, etc. I have a video appointment at the Mayo in a few weeks. After the turn of the year, MAYO said, one would have to go to MN for a second opinion. In short, I'm very conflicted and on hold. I cancelled my December blood test. Need to think and learn more! Currently being treated by an acupuncturist/TCM herbalist, and hoping for clarity as the year turns. Thanks to all for their stories; I'm devouring them!