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Immunotherapy - Keytruda for colorectal cancer

Colorectal Cancer | Last Active: May 27 8:48pm | Replies (36)
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@mercator

On Monday, Dec. 5, I will have my fourth Keytruda infusion for anal cancer. I have been extremely fatigued since beginning infusions; is this normal? Also, no hallucinations, but strange dreams. Anyone else?

After Monday's infusion I will have a CT scan and MRI, and meeting with medical team on Dec. 15 to get results so far and determine future course. I am quite apprehensive.

Mike NH

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Replies to "On Monday, Dec. 5, I will have my fourth Keytruda infusion for anal cancer. I have..."
Amanda Roe | @amandajro | Dec 4, 2022

Hello @mercator and welcome to Mayo Clinic Connect. I wanted to more quickly connect you with previous comments from members as well as other members too, so you will notice that I have moved your post into an existing discussion on the same topic, which you can find here:

- Immunotherapy - Keytruda for colorectal cancer: https://connect.mayoclinic.org/discussion/immunotherapy-keytryda/

Members @bjs06 @sundance6 and @virgo1952 have been part of this discussion and may be able to share more with you.

Have you shared your fatigue with your oncologist?

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cnso | @cnso | Dec 6, 2022

I was on Pembrolizumab (Keytruda) for 5 years for Colorectal cancer. I was diagnosed in Oct. of 2014 after other treatments of Chemotherapy Radiation and Targeted therapies, I was put on Keytruda in April of 2017. Last dose was Jan. 2022.

I remember being extremely fatigued at the beginning but I had been doing other treatments prior to that so I wasn't sure if it was from the Keytruda. I know that everyone has different symptoms from medications that they take so it is always imortant to tell your doctor and care team nurse how you are feeling.

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