Hi, I am just discovering this page. About a week after I got my second shot, I began to feel sick. I thought that Lyme had come back, and the doctor put me on doxycycline. In early May I told her it was not working so they put me on a prednisone script. I was fine, and shortly after I was walking rather weekly. Got another script so I could walk my daughter down for her Wedding. About 20 days after that I ended up in the hospital and have been on prednisone ever since. The good news is I am down to only 4 mg, however, it has been a crazy rollercoaster ride. I get tired, have pain, and if I forget my meds or when I reduce - the pain comes on like running into a brick wall.