How do you prevent testosterone levels from going up again?

First, start thinking “how can I cure this?”… not how we can treat it. Your doctors are fully involved in treating this, it’s how they get paid. It’s up to you to learn how to curate. I’ve been on Lupron for 13 years and it still being effective. There are several other medication’s that work as well or similar to Lupron. Lupron seems to be the preferred choice. When my tutor, strong level changed, they gave me an additional pill. I would encourage you to keep on this regime and also add prayer and see a naturopathic physician to change your diet. I eat almost no carbs, and no sugar. Plus many minerals and vitamins. Good luck on this journey!

Keep in mind there are generally three ways testosterone plays in prostate cancer.

First and foremost, testosterone produced by the testicles. Lupron is designed to shut that off. How long it does that varies, for some, it is a "short" time. For others, "long."

There are sone who advocate for intermittent ADT as both a way to extend the time to resistance and add to quality of life. You may want to discuss with your medical team after you do your homework on it. If you do, have clear criteria and decision points for stopping, actively monitoring while off ADT and restarting.

Another source of testosterone is the adrenal glands. You may want to discuss doublet or triplet therapy with your medical team, again, after doing your homework, as those regimens include ADT agents which shut down production of testosterone from the adrenal glands.

Finally, there is a possibility if I understand correctly of PCa cells able to produce trans use their own testosterone. If my understanding of that is correct then the doublet or triplet therapy can include agents which stop that.

If you have not already, do an internet search for recent videos by Dr. Kwon. Many, myself included find them informative and useful in formulating a treasure strategy with my medical team.

I echo dirtdancer in this may be a window of a cure though the common thinking is one PCa is advanced is not curable. TgT requires an aggressive approach involving imaging and then an aggressive approach in treatment, thus my comments on doublet or triplet therapy.

If your husband is on Lupron alone, mono therapy then it may be time to have a discussion with his medical team about " it interested in population based medicine, aka standard of care. You want treatment that is specific to his PCa and the outcomes you are seeking, a cure, durable remission...

Kevin

You might look into a newer ADT drug called Zytiga (or Abiraterone ).
It is in pill form and is used in conjunction with Lupron. It has been very successful for me (so far). Zytiga is expensive but is available from the VA.
Non Veterans can look into grants or other means to afford the drug.
There are other Second Generation ADT Therapies that also have good results.
Good luck

Just more FYI…. I took Zytiga in conjunction with Lupron for about nine years. The $15,000 monthly fee for the Zytiga was paid for by a charity organization. The Zytiga quit being as effective and so I’m now on Ebearla. It started off effective. But I’m starting year 14 and so have numbers for testosterone, running less than 100, with 650 being an average for a male not being treated. Occasionally, mine will be as low as 27. My PSA has been from .1 all the way up to 30. So I battle a different enemy. After my last bout of radiation, and the addition of many more minerals and vitamins, plus diet change plus prayer I have got my PSA back down in the 10 range. I’m hoping to see it below six, so then I can avoid chemical infusion treatment, which is what they want to do next, and where I will obviously be sick and lose all my hair and all my energy again. UGG.

On Zolodex and my testosterone is zero <.o4 yet my PSA rising 1.2 4.22.5.23 and now 6.6

I'm stage 4 castrate sensitive metastatic to the L2 which was nuked

IDEAS Why is it rising

Ask your Doctor?

He won’t answer clearly because he can’t. But something- testes, adrenal glands- are producing PSA markers, probably testosterone? Or another cancer has started? ( my prostate cancer had metastasized into bone cancer by the time they found it and so my PSA rise was associated with bone cancer according to my doctor…… Go figure.) I would talk to your doctor about changing to another drug and maybe adding Zytiga or Ebearla. These are just suggestions, as I am not a doctor, but it is the treatment path I am on. A pet scan would be very helpful at this time. (PET)

While the adrenal glands may release minor amounts of Testorone they release luteinising hormone that stimulate the gonads to produce testorone.

At least that is the way it was explained to me.