Hi @mandic, you are obviously very worried for your sister. People with sickle cell can experience periodic episodes, called pain crises, that can be painful and cause . Pain develops when sickle-shaped red blood cells block blood flow through tiny blood vessels to your chest, abdomen and joints. The pain varies in intensity and can last for a few hours to a few days. During sickle cell crisis, platelet counts can also decline in the initial phases and rise later during recovery.

Fellow members like @derikburger @jrwilli1 @loribmt @hlmcneely @eibsee1948 have experienced low platelet counts, however not related to sickle cell.

Is your sister currently in sickle cell crisis?